1. 教育状况

1998.09-2002.07：沈阳农业大学畜牧系，学士

2002.09-2005.07：中国农业大学动物营养与饲料科学系，硕士研究生

2009.09-2013.07：东北农业大学动物营养与饲料科学系，博士研究生

2014.10-2020.07：东北农业大学生物学，博士后

2016.03-2017.03：美国密西西比洲立大学，访问学者

2．工作经历

2005.07-2012.05，黑龙江职业学院，动物科学技术学院，助教、讲师

2012.06-2013.08，东北农业大学，动物科学技术学院，讲师

2013.09-2018.08，东北农业大学，动物科学技术学院，副教授

2018.09-至今，东北农业大学，动物科学技术学院，教授

主要成果

近年来董娜教授针对生猪绿色健康养殖技术方面开展了大量研究工作，现任国家生猪产业体系岗位科学家，黑龙江省杰出青年，东北农业大学“杰出学者”。主持国家十四五重点研发计划课题1项、区域创新发展联合基金重点支持项目等国家自然基金3项、黑龙江省杰出青年基金等省自然科学基金项目3项以及中国博士后特别资助等课题4项。研究成果已在国内外学术期刊发表论文60余篇，其中第一作者及通讯SCI文章27篇，单篇影响因子最高19.709，影响因子10以上8篇，5以上23篇，ESI高被引论文3篇，他引共计2000余次。第一发明人授权国家发明专利共8件。现任哈尔滨市政协委员、中国畜牧兽医学会动物营养分会理事、黑龙江省畜牧兽医学会理事。

3.代表性论文

1.Xue Chenyu, Dong Na*, Shan Anshan*. Putative role of STING-mitochondria associated membrane crosstalk in immunity. Trends in Immunology. 2022;43(7):513-522. doi:10.1016/j.it.2022.04.011. (IF19.709)

2.Xue Chenyu, Lv Hao, Li Ying, Dong Na*, Wang Yanhui, Zhou Jiale, Shi Baoming, Shan Anshan*. Oleanolic acid reshapes the gut microbiota and alters immune-related gene expression of intestinal epithelial cells. Journal of the Science of Food and Agriculture. 2022;102(2):764-773. doi:10.1002/jsfa.11410. (IF4.125)

3.Lv Hao, Jia Hongpeng, Cai Wenjie, Cao Rujing, Xue Chenyu, Dong Na*. Rehmannia glutinosa polysaccharides attenuates colitis via reshaping gut microbiota and short-chain fatty acid production. Journal of the Science of Food and Agriculture. 2022. doi:10.1002/jsfa.12326. (IF4.125)

4.Li Ying, Cai Wenjie, Ai Zichun, Xue Chenyu, Cao Rujing, Dong Na*. Protective effects of sinomenine hydrochloride on lead-induced oxidative stress, inflammation, and apoptosis in mouse liver. Environmental Science and Pollution Research. 2022. doi:10.1007/s11356-022-22386-1. (IF5.190)

5.Gao Chenzhe, Koko Marwa Yagoub Farag, Ding Mingxing, Hong Weichen, Li Jianping, Dong Na*, Hui Mizhou. Intestinal alkaline phosphatase (IAP, IAP enhancer) attenuates intestinal inflammation and alleviates insulin resistance. Frontiers in Immunology. 2022. doi:10.3389/fimmu.2022.927272. (IF8.786)

6.Lv Hao, Li Ying, Xue Chenyu, Dong Na*, Bi Chongpeng, Shan Anshan*. Aquaporin: targets for dietary nutrients to regulate intestinal health. Journal of Animal Physiology and Animal Nutrition. 2022;106(1):167-180. doi:10.1111/jpn.13539. (IF2.718)

7.Gao Chenzhe, Hui Mizhou, Dong Na*, Koko Marwa Yagoub Farag. Extraction, purification, and in vitro biological activities of intestinal alkaline phosphatase from pig intestine mucous waste. Journal of Food Processing and Preservation. 2022. doi:10.1111/jfpp.17023. (IF2.609)

8.Fang Yuxin, Zhu Yunhui, Li Ling, Lai Zhenheng, Dong Na*, Shan Anshan*. Biomaterial-interrelated bacterial sweeper: simplified self-assembled octapeptides with double-layered trp zipper induces membrane destabilization and bacterial apoptosis-like death. Small Methods. 2021;5(12):e2101304. doi:10.1002/smtd.202101304. (IF15.367)

9.Xue Chenyu, Li Ying, Lv Hao, Zhang Lei, Bi Chongpeng, Dong Na*, Shan Anshan*, Wang Jiali. Oleanolic acid targets the gut-liver axis to alleviate metabolic disorders and hepatic steatosis. Journal of Agricultural and Food Chemistry. 2021;69(28):7884-7897. doi:10.1021/acs.jafc.1c02257. (IF5.895)

10.Li Ying, Lv Hao, Xue Chenyu, Dong Na*, Bi Chongpeng, Shan Anshan*. Plant polyphenols: potential antidotes for lead exposure. Biological Trace Element Research. 2021;199(10):3960-3976. doi:10.1007/s12011-020-02498-w. (IF4.081)

11.Wang Chensi, Shao Changxuan, Fang Yuxin, Wang Jiajun, Dong Na*, Shan Anshan*. Binding loop of sunflower trypsin inhibitor 1 serves as a design motif for proteolysis-resistant antimicrobial peptides. Acta Biomaterialia. 2021;124:254-269. doi:10.1016/j.actbio.2021.01.036. (IF10.633)

12.Zhang Lei, Lv Hao, Li Ying, Dong Na*, Bi Chongpeng, Shan Anshan*, Wu Zhihan, Shi Baoming, Sodium houttuyfonate enhances the intestinal barrier and attenuates inflammation induced by Salmonella typhimurium through the NF-κB pathway in mice. International Immunopharmacology. 2020;89:107058. (IF5.714)

13.Dong Na, Xue Chenyu, Zhang Lei, Zhang Tingting, Wang Chensi, Bi Chongpeng, Shan Anshan*. Oleanolic acid enhances tight junctions and ameliorates inflammation in salmonella typhimurium-induced diarrhea in mice via the TLR4/NF-κB and MAPK pathway. Food & Function. 2020;11(1):1122-1132. doi:10.1039/c9fo01718f. (IF6.317)

14.Dong Na, Li Xinran, Xue Chenyu, Zhang Lei, Wang Chensi, Xu Xinyao, Shan Anshan*. Astragalus polysaccharides alleviates LPS-induced inflammation via the NF-κB/MAPK signaling pathway. Journal of Cellular Physiology. 2020;235(7-8):5525-5540. doi:10.1002/jcp.29452. (IF6.513)

15.Dong Na, Li Xinran, Xue Chenyu, Wang Chensi, Xu Xinyao, Bi Chongpeng, Shan Anshan*, Li Deshan. Astragalus polysaccharides attenuated inflammation and balanced the gut microflora in mice challenged with salmonella typhimurium. International Immunopharmacology. 2019;74:105681. doi:10.1016/j.intimp.2019.105681. (IF5.714)

16.Dong Na, Xu Xinyao, Xue Chenyu, Wang Chensi, Li Xinran, Bi Chongpeng, Shan Anshan*. Ethyl pyruvate inhibits LPS induced IPEC-J2 inflammation and apoptosis through p38 and ERK1/2 pathways. Cell Cycle. 2019;18(20):2614-2628. doi:10.1080/15384101.2019.1653106. (IF5.173)

17.Dong Na, Xu Xinyao, Xue Chenyu, Wang Chensi, Li Xinran, Shan Anshan*, Xu Li, Li Deshan. Ethyl pyruvate protects against salmonella intestinal infection in mice through down-regulation of pro-inflammatory factors and inhibition of TLR4/MAPK pathway. International Immunopharmacology. 2019;71:155-163. doi:10.1016/j.intimp.2019.03.019.(IF5.714)

18.Dong Na, Wang Chensi, Li Xinran, Guo Yuming, Li Xiaoli, Shan Anshan*. Simplified head-to-tail cyclic polypeptides as biomaterial-associated antimicrobials with endotoxin neutralizing and anti-inflammatory capabilities. International Journal of Molecular Sciences. 2019;20(23):5904. doi:10.3390/ijms20235904. (IF6.208)

19.Dong Na, Wang Chensi, Zhang Tingting, Zhang Lei, Xue Chenyu, Feng Xinjun, Bi Chongpeng, Shan Anshan*. Bioactivity and bactericidal mechanism of histidine-rich β-hairpin peptide against gram-negative bacteria. International Journal of Molecular Sciences. 2019;20(16):3954. doi:10.3390/ijms20163954. (IF 6.208)

20.Dong Na, Wang Zhihua, Chou Shuli, Zhang Licong, Shan Anshan*, Jiang Junguang. Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1. Chemical Biology & Drug Design. 2018;91(5):1017-1029. doi:10.1111/cbdd.13165. (IF2.729)

21.Dong Na, Chou Shuli, Li Jiawei, Xue Chenyu, Li Xinran, Cheng Baojing, Shan Anshan*, Xu Li. Short symmetric-end antimicrobial peptides centered on β-turn amino acids unit improve selectivity and stability. Frontiers in Microbiology. 2018;9:2832. doi:10.3389/fmicb.2018.02832. (IF 6.064)

22.Dong Na, Li Xinrang, Xu Xinyao, Lv Yinfeng, Li Zhongyu, Shan Anshan*, Wang Jiali. Characterization of bactericidal efficiency, cell selectivity and mechanism of short interspecific hybrid peptides. Amino Acids. 2018;50(3-4):453-468. (IF3.789)

23.Dong Na, Zhu Xin, Chou Shuli, Shan Anshan*, Li Weizhong, Jiang Junguang. Antimicrobial potency and selectivity of simplified symmetric-end peptides. Biomaterials. 2014;35(27):8028-8039. doi:10.1016/j.biomaterials.2014.06.005. (IF15.304)

24.Dong Na, Zhu Xin, Lv Yinfeng, Ma Qingquan, Jiang Junguang, Shan Anshan*. Cell specificity and molecular mechanism of antibacterial and antitumor activities of carboxyl-terminal RWL-tagged antimicrobial peptides. Amino Acids. 2014;46(9): 2137-2154. (IF= 3.789)

25.Dong Na, Ma Qinquan, Shan Anshan*, Lv Yinfeng, Hu Wanning, Gu Yao, Li Yuzhi. Novel design of short antimicrobial peptides derived from the bactericidal domain of avian β-defensin-4. Protein and Peptide Letters. 2012;19(11):1212-1219. doi:10.2174/092986612803217006. (IF1.927)

26.Dong Na, Ma Qingquan, Shan Anshan*, Lv Yinfeng, Hu Wanning, Gu Yao, Li Yuzhi. Strand length-dependent antimicrobial activity and membrane-active mechanism of arginine- and valine-rich β-hairpin-like antimicrobial peptides. Antimicrobial Agents and Chemotherapy. 2012;56(6):2994-3003. doi:10.1128/aac.06327-11. (IF5.938)

27.Dong Na, Ma Qingquan, Shan Anshan*, Wang Liang, Sun Wenyu, Li Yuzhi. Influence of truncation of avian β-defensin-4 on biological activity and peptide-membrane interaction. Protein and Peptide Letters. 2012;19(4):430-438. doi:10.2174/092986612799789323. (IF1.927)

25.方禹鑫,李玲,付文华,董娜,单安山.抗菌肽RIKL的分子设计及生物学活性分析.生物工程学报,2022,38(01):174-184.

26.陈茉,白书宁,王行,吕浩,董娜.南瓜多糖对大肠杆菌感染小鼠肠道损伤的保护作用及其机制研究.动物营养学报,2021,33(12):7070-7077.

27.徐欣瑶,董娜,李欣然,杨洋,王志华,单安山.不同疏水性氨基酸对α-螺旋抗菌肽生物学活性的影响.畜牧兽医学报,2019,50(04):791-801.

授权专利

1. 董娜等,2022,一种抗菌肽WR及其透明质酸包被物和应用. ZL202111332538.9

2. 董娜等,2022,一种衍生自蝎毒的抗菌肽及制备方法和应用. ZL202010234847.1

3. 董娜等,2022,一种衍生自肉食杆菌素的抗菌肽及制备方法和应用. ZL202010234601.4

4. 董娜等,2022,一种线性抗菌肽及其制备方法和应用. ZL202010234604.8

5. 董娜等,2018,高细胞选择性的环形抗菌肽OIR3及其制备方法和应用. ZL201611075910.1.

6. 董娜等,2018,一种高效α-螺旋抗菌肽GV及其制备方法和应用. ZL201611064519.1.

7. 董娜等,2018,一种高效杂交抗菌肽LI及其制备方法和应用. ZL201611075909.9.

8. 董娜等,2018,一种鸡源抗菌肽的衍生肽及其制备方法和应用. ZL201510043726.8.

4.在研课题

1.国家十四五重点研发计划课题，新型饲用活性蛋白（肽）的创制与智造，400万，2022.12-2027.11，主持人

2.黑龙江省自然科学基金杰出青年项目，饲用抗菌肽调控肠道菌群介导的粘膜免疫分子机制研究，50万，2022.07-2025.07，主持人

3.国家现代生猪产业技术体系-饲养管理与养殖环境控制，300万，2022.09-2026.12，岗位专家

4.国家自然科学基金-区域创新发展联合基金重点项目，猪靶向抗菌肽构效关系及其乳酸菌表达传递系统构建和作用机理研究，269万，2022.01-2025.12，主持人

5.国家自然科学基金面上项目，基于TLR4/NF-κB信号通路研究齐墩果酸调控仔猪肠道黏膜免疫的分子机制，59万，2020.01-2023.12，主持人

6.黑龙江省自然基金引导项目，基于TLR4/MAPK途径研究丙酮酸乙酯对猪肠道免疫应激的保护作用机理，10万，2019.07-2022.07，主持人

7.国家自然科学基金青年基金项目，枯草芽孢杆菌细胞壁组分调控IPEC-J2细胞抗菌肽表达及其信号转导机理，20万，2016.01-2018.12，主持人

8.中国博士后特别资助，丁酸钠调控猪肠膜IPEC-J2细胞抗菌肽表达及其分子机制，15万，2016.01-2018.12，主持人

9.黑龙江省自然科学青年基金项目，全新β-折叠型抗菌肽的分子设计及稳定性研究，5万，2015.01-2017.12，主持人

10.东北农业大学“学术骨干”项目，丁酸钠调控猪肠膜细胞抗菌肽表达及其分子机制，10万，2016.01-2018.12，主持人

11.中国博士后科学基金面上项目，益生菌细胞壁组分调控猪肠膜细胞抗菌肽表达的机理研究，5万，2016.01-2017.12，主持人

12.黑龙江省博士后科学基金面上项目，猪肠源PR-39抗酶分子设计及抑菌机理研究，10万，2015.01-2017.12，主持人