1．教育状况

2007.09-2011.06：黑龙江八一农垦大学，动物科技学院，动物药学专业，学士

2011.09-2014.06：东北农业大学，动物医学学院，预防兽医学专业，硕士

2014.09-2017.06：东北农业大学，动物科学技术学院，动物营养与饲料科学专业，博士

2．工作经历

2017.07-2020.08 东北农业大学动物科学技术学院 讲师

2020.09-2025.09 东北农业大学动物科学技术学院 副教授

2025.09-至今 东北农业大学动物科学技术学院 教授

3.代表性论文

[1] Ziwen Ma, Xin Wen, Yahan Zhang, Zichun Ai, Xinyi Zhao, Na Dong,Xiujing Dou* and Anshan Shan*. Thymol Alleviates Colitis by Modulating Intestinal Barrier Damage, Gut Microbiota, and Amino Acid Metabolic Pathways. Journal of Agricultural and Food Chemistry. 2025;73(12):7211-7227.

[2] Lujia Gao, Chen Liu, Jiaqi Wu, Ying Cui, Man Zhang, Chongpeng Bi, Anshan Shan andXiujing Dou*. EGCG improve meat quality, restore lipid metabolism disorder and regulate intestinal flora in high-fat fed broilers[J]. Poultry Science, 2025;104:104875.

[3] Shuo Jia, Junhan Gao, Jing Fu, Chongpeng Bi,Xiujing Douand Anshan Shan*. Effect of Oral Antimicrobial Peptide R7I Against Epidemic Enteropathogenic Neisseria in Geese (Anser cygnoides orientalis).Animals,2025;15(20),2939-2939.

[4] Di Yan, Guoyang Wei, Zichun Ai, Shuang Song, Licong Zhang, Na Dong,Xiujing Dou* and AnshanShan*. CXCR2, as a key regulatory gene of HDP-PG-1, maintains intestinal mucosal homeostasis. International Journal of Biological Macromolecules. 2024 Jun;269(Pt 2):132025.

[5]Xiujing Dou, Di Yan, Siqi Liu, Nan Gao, Ziwen Ma, Zixuan Shi, Na Dong, Anshan Shan*. Host defense peptides in nutrition and diseases: A contributor of immunology modulation. Journal of Agricultural and Food Chemistry. 2023, 71(7), 3125–3140.

[6]Xiujing Dou, Ziwen Ma, Di Yan, Nan Gao, Zhongyu Li, Yang Li, Xingjun Feng, Lingxue Meng and Anshan Shan*.Sodium butyrate alleviates intestinal mucosal injury and microbial flora disturbance induced by lipopolysaccharide in rats. Food & Function, 2022, 13(3), 1360-1369.

[7]Xiujing Dou, Di Yan, Siqi Liu, Lujia Gao, Anshan Shan*. Thymol Alleviates LPS-Induced Liver Inflammation and Apoptosis by Inhibiting NLRP3 Inflammasome Activation and the AMPK-mTOR-Autophagy Pathway. Nutrients, 2022, 14(14), 2809.

[8] Nan Gao#,Xiujing Dou#, Yang Yang, Di Yan, Ziwen Ma, Chongpeng Bi, Anshan Shan*. Tryptophan promotes intestinal immune defense through boosting endogenous defensin expression tightly related CaSR-metabolic pathways[J]. Journal of Agricultural and Food Chemistry, 2021. 69 (45), 13460-13473.

[9]Xiujing Dou#, Nan Gao#, Jing Lan, Junlan Han, Yang Yang, and Anshan Shan*, TLR2/EGFR are two sensors for pBD3 and pEP2C induction by sodium butyrate independent of HDAC inhibition[J]. Journal of Agricultural and Food Chemistry, 2020, 68(2), 512-522

[10] Jing Lan#,Xiujing Dou#, Jiawei Li, Yang Yang, Chenyu Xue, Chenxi Wang, Nan Gao, and Anshan Shan*. L-arginine ameliorates lipopolysaccharide-induced intestinal inflammation through inhibiting the TLR4/NF-κB and MAPK pathways and stimulating β-defensins expression in vivo and in vitro[J]. Journal of Agricultural and Food Chemistry, 2020, 68(9), 2648-2663

[11]Xiujing Dou#, Nan Gao, Di Yan, Anshan Shan*. Sodium Butyrate Alleviates Mouse Colitis by Regulating Gut Microbiota Dysbiosis[J]. Animals, 2020, 10(7), 1154.

[12]Xiujing Dou#, Yang Li#, Junlan Han, Dante S. Zarlenga, Weijuan Zhu, Xiaofeng Ren, Na Dong, Xunliang Li* and Guangxing Li*, Lipid raft enriched cholesterol is a key determinant for entry and post-entry stage of porcine rotavirus infection, BMC Veterinary Research, 2018, 14(1): 45

[13]Xiujing Dou#, Junlan Han#, Qiuyuan Ma, Baojing Cheng, Anshan Shan*, Nan Gao and Yu Yang. TLR2/4-mediated NF-κB pathway combined with the histone modifcation regulates β-defensins and interleukins expression by sodium phenyl butyrate in porcine intestinal epithelial cells[J]. Food & Nutrition Research, 2018, 62: 1493

[14]Xiujing Dou, Xin Zhu, Jiajun Wang, Na Dong, Anshan Shan*, Novel design of heptad amphiphiles to enhance cell selectivity, salt resistance, and anti-biofilm properties and their membrane-disruptive mechanism, Journal of Medicinal Chemistry, 2017, 60(6), 2257-2270.

[15]Xiujing Dou, Junlan Han, Wentao Song, Na Dong, Xinyao Xu, Wei Zhang, Anshan Shan*, Sodium butyrate improves porcine host defense peptide expression and relieves the inflammatory response upon toll-like receptor 2 activation and histone deacetylase inhibition in porcine kidney cells, Oncotarget, 2017, 8(16): 26532-26551

授权发明专利

1.（第一发明人）窦秀静，赵聪，李洋，单安山，李仲玉。一种防御素样免疫调节十四肽 RV14 及其制备方法和应用（授权）专利号 ZL202111047861.1。

主持课题

1. 国家自然科学基金面上项目，“EGCG增强仔猪肠黏膜免疫的肠神经信号传递机制”58万元，2022.01-2025.12，主持

2. 国家自然科学基金青年项目“苯基丁酸钠调控猪源宿主防御肽转录与合成的分子机制”26万元，2019.01-2021.12，主持

3. 中国博士后科学基金第14批特别资助“ssc-miR-29a-5p对猪源抗菌肽表达的调控机制研究”18万元，2022.1-2024.12，主持

4. 中央支持地方高校改革发展资金优秀青年项目“EGCG调控肠神经系统增强仔猪免疫的效果及机制”10万元，2022.01-2024.12，主持

5. 黑龙江省博士后特别资助项目（博士后青年英才计划）”MicroRNAs对猪源抗菌肽表达的调控机制研究”20万元，2021.01-2023.12，主持

6. 黑龙江省普通本科高等学校青年创新人才项目“百里香酚促进肠道上皮细胞增殖的分子机制”10万元，2021.01-2023.12，主持

7. 黑龙江省自然科学基金面上项目“组氨酸去乙酰化抑制对猪源抗菌肽表达调控的分子机制”6万元，2018.07-2021.07，主持

8. 中国博士后科学基金面上资助项目“苯基丁酸钠对猪肠上皮细胞防御肽基因表达的调控机制”5万元，2017.10-2019.10，主持

9. 黑龙江省博士后资助面上项目“苯基丁酸钠对猪源抗菌肽基因表达调控的信号转导机制”10万元（一等），2017.10-2020.10，主持

10. 东北农业大学东农学者计划青年才俊“组氨酸修饰依赖的抗菌肽调控对猪的免疫防御机理”6万，2018.12-2021.12，主持

11. 东北农业大学东农学者计划“学术骨干”，10万，主持

13. 黑龙江省自然科学基金优秀青年项目“EGCG 改善高脂猪肠功能紊乱的菌群-肠神经肽机制研究”10万元，2023.07-2026.06，主持