张丽聪，女，高级实验师，专业硕士导师。主要从事饲用抗生素替代及功能性饲料添加剂研发工作，聚焦抗菌肽的构效关系、重组制备及在畜禽生产中的应用研究。主持国家自然科学基金青年基金、黑龙江省自然科学基金联合引导项目等科研项目。在LWT-Food Science and Technology、Microbial Cell Factories等期刊发表第一作者/通讯作者论文10篇，获黑龙江省科技进步一等奖1项。承担《饲料分析实验》《饲料与饲养学实验》等本科生课程。

1.学习经历

2008.09-2012.06：东北农业大学动物科学专业，学士

2012.09-2015.06：东北农业大学动物营养与饲料科学专业，硕士

2021.09-至今：东北农业大学动物营养与饲料科学专业，博士

2.工作经历

2015.09-2017.08：东北农业大学动物科学技术学院，助理实验师2019.09-2023.08：东北农业大学动物科学技术学院，实验师

2023.09-至今：东北农业大学动物科学技术学院，高级实验师，专业硕士导师

3.在研课题

[1]国家自然科学基金青年基金，基于螺旋束基序开发“烘焙-沉淀”纯化技术重组制备抗酶解抗菌肽，主持，2025-2027

[2]黑龙江省自然科学基金联合引导项目，基于螺旋束基序开发“烘焙-沉淀“纯化技术重组制备抗酶解抗菌肽，主持，2023-2026

4.代表性成果（本人名字处可标粗；按文章（第一作者或通讯作者）、专著、专利、品种、标准等顺序列出，共计10项以内）：

[1]Zhang, L.,Yang,H.,Liu,Y.,Wu,Q.,Gao,S.,Zhang,L.,Feng,X.,& Shan, A.(2026). Design andchromatography-freepurification of arecombinanthelix-bundle AMP withpotentantibacterialactivity forporkpreservation.LWT-Food Science and Technology,242: 119140.https://doi.org/10.1016/j.lwt.2026.119140.

[2]Zhang, L., Zhang, J., Zang, H., Yin, Z., Guan, P., Yu, C., Shan, A., & Feng, X. (2024). Dietary pterostilbene exerts potential protective effects by regulating lipid metabolism and enhancing antioxidant capacity on liver in broilers.Journal of Animal Physiology and Animal Nutrition,108(4), 921-933.https://doi.org/10.1111/jpn.13941

[3]Zhan, N.#,Zhang, L.#, Yang, H., Zheng, Y., Wei, X., Wang, J., & Shan, A. (2021). Design and heterologous expression of a novel dimeric LL37 variant inPichia pastoris.Microbial Cell Factories,20(1).https://doi.org/10.1186/s12934-021-01635-x

[4]Zhang, L. C., Guo, T., Zhan, N., Sun, T. T., & Shan, A. S. (2021). The Effects of the antimicrobial peptide WK3 on diarrhea, growth performance and intestinal health of weaned piglets challenged with enterotoxigenicEscherichia coliK88.Food & Nutrition Research,65.https://doi.org/ARTN344810.29219/fnr.v65.3448

[5]Zhang, L. C., Wei, D. D., Zhan, N., Sun, T. T., Shan, B. D., & Shan, A. S. (2020). Heterologous expression of the novel α-helical hybrid peptide PR-FO inBacillus subtilis.Bioprocess and Biosystems Engineering,43(9), 1619-1627.https://doi.org/10.1007/s00449-020-02353-1

[6]Zhang, L.,Li, X., Zhan, N., Sun, T., Li, J., & Shan, A. (2020). Maltose Induced Expression of Cecropin AD by SUMO Technology inBacillus subtilisWB800N.The Protein Journal,39(4), 383-391.https://doi.org/10.1007/s10930-020-09908-x

[7]Zhang, L. C.,Li, G. Q., Zhan, N., Sun, T. T., Cheng, B. J., Li, Y. B., & Shan, A. S. (2019). Expression of aPseudomonas aeruginosa-targeted antimicrobial peptide T9W inBacillus subtilisusing a maltose-inducible vector.Process Biochemistry,81, 22-27.https://doi.org/10.1016/j.procbio.2019.03.008

[8]Zhang, L. C., Li, X. D., Wei, D. D., Wang, J., Shan, A. S., & Li, Z. Y. (2015). Expression of plectasin inBacillus subtilisusing SUMO technology by a maltose-inducible vector.Journal of Industrial Microbiology & Biotechnology,42(10), 1369-1376.https://doi.org/10.1007/s10295-015-1673-y

[9]程宝晶,李仲玉,张丽聪*.霉菌毒素对畜禽危害及其中毒防治手段的研究进展.饲料工业,2025,46,(12):127-135.https://doi.org/10.13302/j.cnki.fi.2025.12.019.

[10]张丽聪,张凌玮,刘玥垚，高思雨，展娜，冯兴军*，单安山*.抗菌肽重组制备:在微生物工厂中产量优化策略.微生物学通报,2025,52,(10):4424-4440.https://doi.org/10.13344/j.microbiol.china.250175.